The times are changing, and the old ways of working (business-as-usual) are not leading to the results we need. Normally we would then turn to innovation but in this class we will argue that these future challenges are so fundamentally different that innovation-as-usual is not working anymore. To take charge of future challenges, we need to explore new forms of transformative design and entrepreneurship that empower us to look critically at the modus operandi (the current paradigm, the rules of the game) and sketch out new paradigms for the future.